Assessment of Serum Apelin Levels in Girls with Anorexia Nervosa
| Autor: | Joanna Oświęcimska, Elzbieta Swietochowska, Antoni Dyduch, Zofia Ostrowska, Katarzyna Ziora, Dariusz Ziora, Ewa Klimacka-Nawrot, Barbara Błońska-Fajfrowska, Małgorzata Stojewska |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Anorexia Nervosa Adolescent viruses Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Context (language use) Anorexia Biochemistry Body Mass Index Immunoenzyme Techniques Endocrinology stomatognathic system Internal medicine medicine Humans Obesity Child media_common business.industry Body Weight Biochemistry (medical) Appetite social sciences medicine.disease Body Height Apelin body regions Eating disorders Adipose Tissue Anorexia nervosa (differential diagnoses) Body Composition Intercellular Signaling Peptides and Proteins Female Poland medicine.symptom business Body mass index Biomarkers |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 95:2935-2941 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2009-1958 |
| Popis: | Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. Objective: Our objective was to assess serum APE concentrations in girls with AN. Design, Participants, and Setting: APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). Results: Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. Conclusions: We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. |
| Databáze: | OpenAIRE |
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