Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities
| Autor: | R Storb, R.P. Witherspoon, K Doney, F R Appelbaum, Paul L. Martin, Terry Furlong, Keith M. Sullivan, R A Nash, C Anasetti, H J Deeg |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Drug Resistance Graft vs Host Disease chemical and pharmacologic phenomena Gastroenterology Tacrolimus Internal medicine medicine Humans Transplantation Homologous Child Bone Marrow Transplantation Retrospective Studies Transplantation Chemotherapy business.industry Neurotoxicity Hematopoietic Stem Cell Transplantation Peripheral Nervous System Diseases Hematology Middle Aged Ciclosporin medicine.disease Surgery surgical procedures operative Graft-versus-host disease Treatment Outcome Child Preschool Toxicity Acute Disease Hemolytic-Uremic Syndrome Cyclosporine Female Kidney Diseases sense organs Complication business Immunosuppressive Agents medicine.drug |
| Zdroj: | Bone marrow transplantation. 26(9) |
| ISSN: | 0268-3369 |
| Popis: | This retrospective study describes the outcome in 53 patients who had immunosuppressive treatment changed from cyclosporine (CSP) to tacrolimus for resistant acute GVHD (n = 23), hemolytic uremic syndrome (HUS) (n = 13) or CSP-associated neurotoxicity (n = 17). Tacrolimus was administered at doses of 0.03 mg/kg/day intravenously or 0.12 mg/kg/day orally in divided doses, as tolerated. Median time of conversion to tacrolimus after transplant was day 47. Nineteen patients had treatment changed to tacrolimus for resistant acute GVHD grades III or IV, with the median day of conversion being day 49 after transplant. Two of 20 evaluable patients had a complete resolution of GVHD after changing treatment to tacrolimus, with 18 showing no improvement. Eleven evaluable patients had therapy changed to tacrolimus for CSP-associated neurotoxicity at a median of 36 days after transplant. Eight patients had resolution of neurotoxicity and three had partial improvement. Eleven evaluable patients had therapy changed to tacrolimus for HUS at a median of 46 days after transplant. One patient had complete resolution of HUS and 10 showed no response. Side-effects related to tacrolimus included renal toxicity (34%), neurotoxicity (15%) and HUS (9%). Nine (17%) patients remain alive, including six patients who had therapy changed to tacrolimus for CSP-associated neurotoxicity. While often successful for dealing with neurotoxicity, only a rare patient improved after therapy was changed from CSP to tacrolimus for HUS or resistant acute GVHD. |
| Databáze: | OpenAIRE |
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