Cellular Tango
| Autor: | Elisabeth G. Rens, Leah Edelstein-Keshet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rho GTP-Binding Proteins
Polarity (physics) Cell Biophysics Dynamical Systems (math.DS) GTPase Extracellular matrix 03 medical and health sciences 0302 clinical medicine Cell Movement Structural Biology Cell Behavior (q-bio.CB) Cell polarity FOS: Mathematics Cell Adhesion medicine Cell migration Mathematics - Dynamical Systems Molecular Biology GTPase signaling 030304 developmental biology 0303 health sciences Chemistry Cellular Potts model Cell Polarity Cell Biology Adhesion Extracellular Matrix Cell modeling medicine.anatomical_structure FOS: Biological sciences Quantitative Biology - Cell Behavior Cell shape 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Physical biology, 18(6) |
| ISSN: | 1478-3967 |
| Popis: | The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes the contact and adhesion of cell to the extracellular matrix (ECM), while ECM signaling through integrin receptors also affects GTPase activity. We develop and investigate a model for this three-way feedback loop in 1D and 2D spatial domains, as well as in a fully deforming 2D cell shape. The model consists of reaction-diffusion equations solved numerically with open-source software, Morpheus, and with custom-built cellular Potts model simulations. We find a variety of patterns and cell behaviors, including persistent polarity, flipped front-back cell polarity oscillations, and random protrusion-retraction. We show that the observed spatial patterns depend on the cell shape, and vice versa. The cell stiffness and biophysical properties also affect patterning, overall cell migration phenotypes. |
| Databáze: | OpenAIRE |
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