Reciprocal Relationship Between the in Vitro Synthesis and Secretion of Prolactin and Growth Hormone
Autor: | Robert M. MacLeod, Joyce E. Lehmeyer |
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Rok vydání: | 1974 |
Předmět: |
Male
Pituitary gland medicine.medical_specialty In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology Prolactin cell Leucine Internal medicine Cyclic AMP medicine Animals Secretion Estradiol In vitro Prolactin Rats medicine.anatomical_structure Endocrinology Growth Hormone Pituitary Gland Haloperidol Perphenazine Female hormones hormone substitutes and hormone antagonists Intracellular Hormone |
Zdroj: | Experimental Biology and Medicine. 145:1128-1131 |
ISSN: | 1535-3699 1535-3702 |
DOI: | 10.3181/00379727-145-37966 |
Popis: | SummaryA comparison was made of the amount of radioactive leucine incorporated in vitro into prolactin and growth hormone by rat pituitary glands. It was demonstrated that when the production of prolactin is high, the production of growth hormone is low. The converse of this was also observed. The injection of male rats with estradiol or other agents which significantly increased prolactin production caused a decrease in growth hormone production. It is suggested that the pituitary gland tends to produce a constant amount of prolactin and growth hormone and reciprocal changes are brought about by the production of either hormone through some intracellular control mechanism when the hormonal balance is disturbed through a secondary mechanism.We thank Mr. Ronald C. Pace for his excellent technical assistance. |
Databáze: | OpenAIRE |
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