Neural and behavioral correlates of inhibitory control in youths with varying levels of irritability
| Autor: | Jillian Lee Wiggins, Maria Kryza-Lacombe, Nader Amir, Isaac Ray Christian, Michael T. Liuzzi, Danielle E. Palumbo |
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| Rok vydání: | 2019 |
| Předmět: |
Adolescent
media_common.quotation_subject Middle temporal gyrus Neuroimaging Anger Irritability Amygdala Article 03 medical and health sciences 0302 clinical medicine medicine Middle frontal gyrus Humans Child media_common Fusiform gyrus business.industry Brain Magnetic Resonance Imaging Irritable Mood 030227 psychiatry Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Posterior cingulate medicine.symptom business Neuroscience 030217 neurology & neurosurgery Parahippocampal gyrus |
| Zdroj: | J Affect Disord |
| ISSN: | 1573-2517 |
| Popis: | Background Irritability, a relatively lowered threshold for anger, is prevalent in typically and atypically developing youths. Inhibitory control, the ability to suppress behaviors counter to goals, is essential for regulating emotions, including anger. Understanding how irritability relates to behavioral and neural markers of inhibitory control may inform interventions. Methods Youths (N=52; mean age=13.78) completed a Flanker task on an iPad to measure behavioral correlates of inhibitory control; a subsample (n=19; mean age=13.21) additionally completed a similar task while undergoing fMRI acquisition to evaluate inhibitory control on a neural level. Irritability was measured using the Affective Reactivity Index. Associations between irritability and inhibitory control were evaluated behaviorally (via Pearson correlations), and neurally (via ANCOVAs with whole-brain activation and amygdala connectivity). Results fMRI results indicated that higher levels of irritability were associated with aberrant activation (in middle frontal gyrus, amygdala/parahippocampal gyrus, anterior cingulate, lentiform nucleus/striatum) and left amygdala connectivity (with middle temporal gyrus, parahippocampal gyrus, posterior cingulate, fusiform gyrus, and thalamus). Behavioral results were mixed. Limitations Longitudinal studies are needed to characterize changes in neural circuitry and delineate whether the brain profiles precede or are a consequence of symptoms. Larger samples powered to examine multiple irritability-related symptom dimensions will be necessary to elucidate shared vs. disorder-specific irritability mechanisms. Conclusions Findings suggest that pediatric irritability may be related to neural processes involving inhibitory control. Further, findings underscore the importance of neuroimaging in investigating symptom dimensions such as irritability, as neuroimaging may be more sensitive in detecting underlying abnormalities compared to behavioral data alone. |
| Databáze: | OpenAIRE |
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