Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity
Autor: | Sameer N. Goyal, Dharamvir Singh Arya, Umesh B Mahajan, Shreesh Ojha, Chandrgouda R. Patil, Mohanraj Rajesh, Hasan Al Taee |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Aging Cardiotonic Agents Anthracycline medicine.medical_treatment Phytochemicals macromolecular substances Review Article Pharmacology Biochemistry Small Molecule Libraries 03 medical and health sciences 0302 clinical medicine polycyclic compounds Medicine Animals Humans Doxorubicin Cardioprotective Agent lcsh:QH573-671 Irreversible Toxicity Cardiotoxicity lcsh:Cytology business.industry Cancer Cell Biology General Medicine Plants medicine.disease carbohydrates (lipids) 030104 developmental biology 030220 oncology & carcinogenesis business Adjuvant medicine.drug |
Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2016 (2016) |
ISSN: | 1942-0994 1942-0900 |
Popis: | Doxorubicin (DOX) is a potent and widely used anthracycline antibiotic for the treatment of several malignancies. Unfortunately, the clinical utility of DOX is often restricted due to the elicitation of organ toxicity. Particularly, the increased risk for the development of dilated cardiomyopathy by DOX among the cancer survivors warrants major attention from the physicians as well as researchers to develop adjuvant agents to neutralize the noxious effects of DOX on the healthy myocardium. Despite these pitfalls, the use of traditional cytotoxic drugs continues to be the mainstay treatment for several types of cancer. Recently, phytochemicals have gained attention for their anticancer, chemopreventive, and cardioprotective activities. The ideal cardioprotective agents should not compromise the clinical efficacy of DOX and should be devoid of cumulative or irreversible toxicity on the naïve tissues. Furthermore, adjuvants possessing synergistic anticancer activity and quelling of chemoresistance would significantly enhance the clinical utility in combating DOX-induced cardiotoxicity. The present review renders an overview of cardioprotective effects of plant-derived small molecules and their purported mechanisms against DOX-induced cardiotoxicity. Phytochemicals serve as the reservoirs of pharmacophore which can be utilized as templates for developing safe and potential novel cardioprotective agents in combating DOX-induced cardiotoxicity. |
Databáze: | OpenAIRE |
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