False positivity of monospot test in an immunocompetent elderly woman with acute cytomegalovirus infection
| Autor: | Nitipong Permpalung, Natanong Thamcharoen, Suthanya Sornprom, Charles L. Hyman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Congenital cytomegalovirus infection
Virus law.invention Serology Diagnosis Differential law Medicine Humans False Positive Reactions Serologic Tests Infectious Mononucleosis Polymerase chain reaction Aged biology business.industry virus diseases General Medicine False positivity medicine.disease Virology Cytomegalovirus infection Immunology Acute Disease Cytomegalovirus Infections Emergency Medicine biology.protein Female Differential diagnosis Antibody business |
| Zdroj: | The American journal of emergency medicine. 33(10) |
| ISSN: | 1532-8171 |
| Popis: | A 75-year-old woman presented with altered mental status, septic picture, and influenza-like symptoms. Initial investigations revealed atypical lymphocytosis, thrombocytopenia, elevated liver enzymes, and a positive monospot test result. Further investigation showed the Epstein-Barr virus viral capsid antibody IgM/IgG and Epstein-Barr virus DNA by polymerase chain reaction to be negative; however, interestingly her cytomegalovirus (CMV) IgM and IgG were positive, suggesting that her mononucleosis-like syndrome was due to acute CMV infection. Herein, we report the first case of a heterophile-positive mononucleosis syndrome caused by acute CMV infection in an elderly immunocompetent woman. This case conveys that monospot test can yield false-positive result in the setting of acute CMV infection. |
| Databáze: | OpenAIRE |
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