Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study
| Autor: | Muzahir H. Tayebjee, Arun V. Holden, G A Begg, Katrina Bounford, Berthold Stegemann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Defibrillation medicine.medical_treatment Atrial fibrillation Dominant frequency 030204 cardiovascular system & hematology medicine.disease Implantable cardioverter-defibrillator Cardioversion Intracardiac injection 03 medical and health sciences 0302 clinical medicine Internal medicine Ventricular fibrillation cardiovascular system Cardiology Medicine 030212 general & internal medicine Cardiology and Cardiovascular Medicine business Entrainment (chronobiology) Original Research |
| Zdroj: | J Atr Fibrillation |
| ISSN: | 1941-6911 |
| Popis: | Cardioversion and defibrillation by a single high energy shock applied by myocardial or body surface electrodes is painful, causes long term tissue damage, and is associated with worsening long term outcomes, but is almost always required for treatment of ventricular fibrillation . As a initial step towards developing methods that can terminate ventricular arrhythmias painlessly, we aim to determine if pacing stimuli at a rate of 5/s applied via an implantable cardiac defibrillator (ICD) can modify human ventricular fibrillation. In 8 patients undergoing defibrillation testing of a new/exchanged intracardiac defibrillator, five seconds of pacing at five stimuli per second was applied during the 10-20 seconds of induced ventricular fibrillation before the defibrillation shock was automatically applied, and the cardiac electrograms recorded and analyzed. The high frequency pacing did not entrain the ventricular fibrillation, but altered the dominant frequency in all 8 patients, and modulated the phase computed via the Hilbert Transform, in four of the patients. In this pilot study we demonstrate that high frequency pacing applied via ICD electrodes during VF can alter the dominant frequency and modulate the probability density of the phase of the electrogram of the ventricular fibrillation. |
| Databáze: | OpenAIRE |
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