Differential risks of cancer types in people with Parkinson’s disease: A national record-linkage study
| Autor: | Eugene Liat Hui Ong, Raph Goldacre, Michael J Goldacre |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Parkinson's disease Adolescent Disease Malignancy Cohort Studies Young Adult Breast cancer Risk Factors Neoplasms Internal medicine Humans Medicine Child Aged Aged 80 and over business.industry Infant Newborn Infant Cancer Parkinson Disease Middle Aged medicine.disease Confidence interval England Child Preschool Cohort Physical therapy Female Record Linkage Study business |
| Zdroj: | European Journal of Cancer. 50:2456-2462 |
| ISSN: | 0959-8049 |
| Popis: | BACKGROUND: There is evidence that people with Parkinson's disease (PD) have a decreased risk of developing cancer. PD has also variably been shown to be associated with an increased risk of cancers like melanoma and breast. We investigated this relationship in a very large cohort of PD patients. METHODS: We constructed two cohorts of people from an all-England record-linked hospital and mortality dataset spanning 1999-2011. One cohort comprised people with a record of PD; the other comprised people without a record of PD. We 'followed up' these two cohorts to determine observed and expected numbers of people with subsequent primary cancers in each, based on person-years at risk, and calculated standardised rate ratios (RRs). RESULTS: In 219,194 people with PD, the RR for all subsequent primary malignant cancers combined was 0.92 (95% confidence interval (CI) 0.91-0.93). Increased RRs (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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