Continuous extradural infusion of 0.0625% or 0.125% bupivacaine for pain relief in primigravid labour
| Autor: | D. F. Li, M. Rosen, G.A.D. Rees |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Anesthesia Epidural medicine.medical_specialty Time Factors Rate of infusion Pain relief Active labour Pregnancy Infusion Procedure medicine Anesthesia Obstetrical Humans Infusions Parenteral Bupivacaine Local anaesthetic Labor Obstetric business.industry Surgery Regimen Parity Anesthesiology and Pain Medicine Infusion group Anesthesia Female business medicine.drug |
| Zdroj: | British journal of anaesthesia. 57(3) |
| ISSN: | 0007-0912 |
| Popis: | The efficacy of an extradural infusion of 0.0625% or 0.125% bupivacaine was studied in 98 primigravid mothers in active labour. No special measures were taken to posture the mother (except to avoid aorto-caval compression). The study regimen included a control group (no infusion) receiving intermittent top-ups (0.25%. bupivacaine 8-10 ml), two groups receiving bupivacaine 6.25 mg h-1 infusion in different concentrations (0.0625% and 0.125%), a fourth group receiving 0.125% bupivacaine 12.5 mg h-1 infusion, and a fifth group receiving 0.125% bupivacaine 18.75 mg h-1 infusion. The optimum infusion rate was 0.125% bupivacaine 10 ml h-1, at which 69% of primigravid mothers required none or only one "top-up" of 0.25% bupivacaine 8-10 ml during a mean duration of 7.1 h labour. In the group who had no extradural infusion, only 32% of mothers managed with one or no top-up. The median interval between top-ups was increased from 145 min in the no infusion group to 245 min in those mothers receiving 0.125% bupivacaine 10 ml h-1 by infusion. Increasing the rate of infusion to 15 ml h-1 did not improve the results. Spread of local anaesthetic to higher levels was limited (less than T5) so that testing sensory loss at the T5-6 level at 2-hourly intervals should detect accidental spinal blockade resulting from inadvertent intrathecal infusion. |
| Databáze: | OpenAIRE |
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