Preoperative hemoglobin count and prognosis of esophageal cancer, a population-based nationwide study in Finland
| Autor: | Arto Kokkola, Vesa-Matti Pohjanen, Pasi Ohtonen, Simo Laine, Olli Helminen, Tuula Tyrväinen, Ella M.K. Jokela, Antti Valtola, Vesa Toikkanen, Joonas H. Kauppila, Sanna Meriläinen, Ari Ristimäki, Vesa Koivukangas, Eero Sihvo, Raija Kallio, Elina Lietzén, Juha Saarnio, Mika Helmiö, Tuomo Rantanen, Heikki Huhta, Jari Räsänen |
|---|---|
| Přispěvatelé: | HUS Abdominal Center, Department of Surgery, Department of Pathology, HUSLAB, ATG - Applied Tumor Genomics, HUS Heart and Lung Center, III kirurgian klinikka, Helsinki University Hospital Area |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Population 3122 Cancers Esophageal cancer Hemoglobins 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine 030212 general & internal medicine Hemoglobin Mortality education Finland Neoadjuvant therapy Retrospective Studies education.field_of_study business.industry Hazard ratio Retrospective cohort study General Medicine medicine.disease 3126 Surgery anesthesiology intensive care radiology Prognosis Comorbidity 3. Good health Esophagectomy Oncology 030220 oncology & carcinogenesis Cohort Female Surgery business |
| Popis: | Publisher Copyright: © 2021 Background: The prognostic value of preoperative hemoglobin in patients undergoing esophagectomy is unknown. The aim of this study was to examine whether preoperative hemoglobin is associated with prognosis in patients undergoing esophagectomy for cancer. Materials and methods: This was a population-based nationwide retrospective cohort study in Finland, using Finnish National Esophago-Gastric Cancer Cohort (FINEGO). Esophagectomy patients with available preoperative hemoglobin measurement were included. Multivariable cox regression provided hazard ratios (HR) with 95% confidence intervals (CI), adjusted for calendar period of surgery, age at surgery, sex, comorbidity (Charlson Comorbidity Index), tumor histology, tumor stage, neoadjuvant therapy, type of surgery (minimally invasive or open) and annual hospital volume. Results: Of the 1313 patients, 932 (71.0%) were men and 799 (60.9%) had esophageal adenocarcinoma. Overall all-cause mortality was significantly higher in the lowest hemoglobin count tertile (HR 1.26 (1.07–1.47)) compared to the highest tertile, but this association was attenuated after adjustment for confounding. No differences were found between the preoperative hemoglobin groups in the adjusted analyses of 90-day all-cause, 5-year all-cause, and 5-year cancer-specific mortality. Conclusion: In this population-based nationwide study, preoperative hemoglobin count had no independent prognostic significance in esophageal cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|