High serum tumor necrosis factor-alpha levels are associated with lack of response to infliximab in fistulizing Crohn's disease
| Autor: | Segundo Gonzalez, Eva M Deschamps, Jesús Martínez-Borra, J. M. Pérez-Pariente, Luis Rodrigo, Angeles Dieguez, Carlos López-Larrea, Dolores Fuentes, Antonio López-Vázquez, Ruth de Francisco |
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| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
Adult Male Adolescent Fistula medicine.medical_treatment Disease Crohn Disease Gastrointestinal Agents Medicine Humans Prospective Studies skin and connective tissue diseases Prospective cohort study Crohn's disease Hepatology biology Dose-Response Relationship Drug business.industry Interleukin-6 Tumor Necrosis Factor-alpha Gastroenterology Antibodies Monoclonal Middle Aged medicine.disease digestive system diseases Infliximab stomatognathic diseases Cytokine Immunology biology.protein Cytokines Tumor necrosis factor alpha Female Antibody business Complication medicine.drug Acute-Phase Proteins Interleukin-1 |
| Zdroj: | The American journal of gastroenterology. 97(9) |
| ISSN: | 0002-9270 |
| Popis: | Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor-alpha (anti-TNF-alpha), has been effective in the treatment of patients with active Crohn's disease and with fistulas. We investigated the effect of infliximab on circulating cytokines and acute phase proteins in patients with fistulas to determine the clinical response to anti-TNF-alpha.A total of 36 patients with fistulizing Crohn's disease were selected for study. Serum from patients was drawn before the infusion on day 0 and at wk 2, 4, 6, 8, and 10 after completion of treatment. Circulating concentrations of TNF-alpha, interleukin-1beta (IL-1beta), and IL-6 were measured by ELISA. The functional activity of circulating TNF-alpha was assessed by the WEHI 164 TNF-alpha bioassay. Acute phase proteins were also determined.Elevated TNF-alpha, IL-1beta, IL-6, and acute phase proteins were observed in patients with Crohn's disease. Of the patients with fistulas, 22 (61.1%) responded to treatment. Before receiving infliximab, higher levels of serum TNF-alpha were found in patients who did not respond to infliximab compared with those who did (median interquartile range 26, 0-245 pg/ml; n = 14 vs 0, 0-22 pg/ml, n = 22). Patients showed no change in circulating levels of TNF-alpha during the course of the study.This treatment produces a clinical improvement in about two-thirds of CD patients with fistulas. The circulating levels of TNF-alpha are associated with the response to infliximab and could help to identify patients who would benefit from anti-TNF-alpha treatment. |
| Databáze: | OpenAIRE |
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