Effect of prostaglandin I2 and superoxide dismutase on reperfusion injury of warm ischemic lung
| Autor: | Masayosi Okada, Chojiro Yamashita, Hidehiro Yamamoto, Fukumasa Tsuji, Satosi Tobe, Hiroomi Nakamura, Kazuo Nakamura, Hidefumi Oobo |
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| Rok vydání: | 1992 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pulmonary Circulation Ischemia Dogs Edema Medicine Animals Lung business.industry Heparin Superoxide Dismutase Respiratory disease Carbon Dioxide medicine.disease Right pulmonary artery Denervation Epoprostenol Oxygen medicine.anatomical_structure Anesthesia Reperfusion Injury Extravascular Lung Water cardiovascular system Vascular resistance lipids (amino acids peptides and proteins) Surgery Vascular Resistance medicine.symptom Cardiology and Cardiovascular Medicine business Reperfusion injury medicine.drug |
| Zdroj: | The Annals of thoracic surgery. 54(5) |
| ISSN: | 0003-4975 |
| Popis: | A prostaglandin I2 (PGI2) analogue and superoxide dismutase (SOD) were administered to dogs with pulmonary denervation, and their effects on warm ischemic damage to the lung were studied. Twenty-seven adult mongrel dogs were divided into a control group (6 dogs), a PGI2 group (7 dogs), an SOD group (6 dogs), and a heparin group (8 dogs). The left pulmonary hilum was dissected, with PGI2 (1 microgram/kg) being administered to the PGI2 group and heparin (100 U/kg) to the heparin group. Then the left lung was placed in a warm ischemic state for 1 hour. The SOD group also received 20 mg/kg of SOD intravenously 1 minute before reperfusion. Before warm ischemia, immediately after reperfusion, and 1 hour and 2 hours afterward, the blood gases, left pulmonary vascular resistance, and other data were measured under right pulmonary artery clamping. Arterial oxygen tension showed significantly better values in the SOD and PGI2 groups than in the control and heparin groups. The left pulmonary vascular resistance increased with time in the control group but did not increase in the PGI2 group. Pulmonary microangiography showed that dilatation of the pulmonary arterioles was prominent in the PGI2 group. The quantity of pulmonary extravascular fluid was significantly less in the PGI2 and SOD groups than in the control and heparin groups. Histological examination showed marked collapse of capillaries, intraalveolar hemorrhage, and edema in the control and heparin groups, whereas these changes were only slight in the PGI2 and SOD groups.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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