Lactobacillus casei beneficially modulates immuno-coagulative response in an endotoxemia model
| Autor: | Marcela Fátima Medina, Maria Eugenia Monaco, Cecilia Haro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Lipopolysaccharides
Male 0301 basic medicine Lactobacillus casei MICE ENDOTOXEMIA MODEL CIENCIAS MÉDICAS Y DE LA SALUD Lipopolysaccharide Ciencias de la Salud Inflammation 030204 cardiovascular system & hematology Pharmacology Proinflammatory cytokine Sepsis Mice 03 medical and health sciences Tissue factor chemistry.chemical_compound 0302 clinical medicine Oral administration medicine Animals Humans Blood Coagulation Mice Inbred BALB C SEPSIS biology business.industry PROBIOTIC Antithrombin INFLAMMATION-COAGULATION food and beverages Hematology General Medicine medicine.disease biology.organism_classification Endotoxemia Otras Ciencias de la Salud Lacticaseibacillus casei 030104 developmental biology chemistry Cytokines medicine.symptom business medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 29:104-110 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/mbc.0000000000000684 |
| Popis: | The current study aims at evaluating the effect of the oral administration of Lactobacillus casei CERELA (CRL) 431 on parameters implicated in inflammation-coagulation interaction using a model of acute inflammation induced by lipopolysaccharide (LPS) in mice. Six-week-old Balb/c mice were treated with L. casei for 5 consecutive days. Then treated and untreated mice received an LPS injection (L. caseiRLPS and LPS groups, respectively). Liver and kidney were removed, blood samples were obtained, and hemostatic and inflammatory parameters were evaluated at different times post LPS injection. Preventive L. casei administration induced a significant decrease in proinflammatory TNF-A and IL-6 cytokines by decreasing tissue factor expression in liver and kidney. Moreover, the lower expression of tissue factor in the L. caseiRLPS group led to a lower activation of the coagulation system, which was observed by the fast systemic restoration of factors VII and V coagulation factors and antithrombin levels. This study highlights the capacity of L. casei to modulate the hemostatic unbalance in an acute endotoxemia model. Our findings showed the ability of L. casei CRL 431 to regulate the immuno-coagulative response. This fact could be helpful to propose new adjunctive strategies addressed to the restoration of physiological anticoagulant mechanisms in sepsis patients. Fil: Haro, Ana Cecilia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina Fil: Monaco, Maria Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina Fil: Medina, Marcela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina |
| Databáze: | OpenAIRE |
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