Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis
| Autor: | Rylan J. Lundgren, Qiqige Qiqige, Maxime Munch, Benjamin H. Rotstein, Christopher Cooze, Duanyang Kong |
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| Rok vydání: | 2020 |
| Předmět: |
Decarboxylation
Carbazole 010401 analytical chemistry Photoredox catalysis General Chemistry 010402 general chemistry Photochemistry Biochemistry Combinatorial chemistry 01 natural sciences Catalysis 3. Good health 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry Transition metal Isotopes of carbon Molecule Carboxylate |
| Popis: | Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabelling of drug molecules and precursors with [11C]CO2 is demonstrated. |
| Databáze: | OpenAIRE |
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