Measurement of Sunscreen Immune Protection Factors in Humans: A Consensus Paper
| Autor: | Jean Maccario, Peter Wolf, Kevin D. Cooper, Terrence Poon, Delphine Compan, Elma D. Baron, Gary M. Halliday, Franz Quehenberger, Dominique Moyal, Antony R. Young, Anny Fourtanier, Paul T. Seed, Susan L. Walker |
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| Rok vydání: | 2005 |
| Předmět: |
ultraviolet radiation
medicine.medical_specialty Skin Neoplasms Ultraviolet Rays medicine.medical_treatment Dermatology Dermatitis Contact Biochemistry Sun protection factor Antigen Immune Tolerance sunscreens medicine Humans Immunologic Factors Hypersensitivity Delayed Molecular Biology Ultraviolet radiation Sensitization immune protection Single exposure integumentary system Immune protection business.industry consensus paper Contact hypersensitivity Immunosuppression Cell Biology Surgery medicine.anatomical_structure Immune System Immunology Immunologic Techniques Sunlight business Sunscreening Agents |
| Zdroj: | Journal of Investigative Dermatology. 125:403-409 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/j.0022-202x.2005.23857.x |
| Popis: | It is increasingly accepted that sunscreens should protect against ultraviolet radiation (UVR)-induced immunosuppression, with an index of protection that can be compared with the sun protection factor (SPF). Five groups of immunoprotection researchers met to discuss the status of immune protection factor (IPF) evaluation in human skin in vivo. Current methods rely on a suncreen's inhibition of UVR-induced local suppression of the contact hypersensitivity (CHS) response or the delayed-type hypersensitivity (DTH) response, using either the induction or the elicitation arms of these responses. The induction arm of the CHS response has the advantage of being sensitive to a single sub-erythemal exposure of solar-simulating radiation (SSR) that allows a direct comparison with the SPF. This approach, which necessitates sensitization, requires a large number of volunteers and is too labor intensive and time consuming to become a routine method. The elicitation arm of the CHS or DTH responses exploits prior sensitization to contact or recall antigens and has the advantage of being possible to apply on small groups of volunteers. Some current protocols, however, require repeat SSR exposures, which invalidates a direct comparison with SPF that is based on a single exposure. There is a need for a new simpler method of IPF that will have to be validated against existing models. |
| Databáze: | OpenAIRE |
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