A Phase II Study of Sequential Neoadjuvant Gemcitabine and Paclitaxel, Radiation Therapy With Cisplatin and 5-Fluorouracil and Surgery in Locally Advanced Esophageal Carcinoma
| Autor: | Jeffrey J. Sussman, M. M. Safa, Patricia Rose, Kevin P. Redmond, John A. Howington, Laura E. James, Syed A. Ahmad, Irfan Firdaus, Abdul Rahman Jazieh, Andrew M. Lowy, Debasish Roychowdhury, Michael F. Reed |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Esophageal Neoplasms Paclitaxel medicine.medical_treatment Deoxycytidine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoadjuvant therapy Aged Aged 80 and over Chemotherapy business.industry Carcinoma Middle Aged Esophageal cancer medicine.disease Survival Analysis Gemcitabine Neoadjuvant Therapy Surgery Radiation therapy Regimen Treatment Outcome Oncology Female Fluorouracil Cisplatin business Progressive disease Febrile neutropenia medicine.drug |
| Zdroj: | American Journal of Clinical Oncology. 29:555-561 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/01.coc.0000233997.36073.8e |
| Popis: | Objective: To evaluate the feasibility and efficacy of sequential neoadjuvant chemotherapy, chemoradiation, and surgery in patients with locally advanced esophageal cancer. Patients and Methods: There were 29 patients who received paclitaxel 150 mg/m 2 and gemcitabine 3000 mg/m 2 2 weeks apart. Two weeks later, patients received cisplatin 75 mg/m 2 and 5-fluorouracil (5-FU) 1000 mg/m 2 /d continuous infusion for 4 days with concurrent radiotherapy in 15 fractions to a total dose of 4000 cGy. After 6 weeks, cisplatin and 5-FU were repeated at the above doses. After 4 to 6 weeks, patients were restaged and underwent surgical resection. Results: All 29 patients completed the prescribed gemcitabine, paclitaxel, and radiation therapy. Febrile neutropenia occurred in 1 patient and 4 patients received growth factor support. After neoadjuvant treatment, 1 patient refused surgery, 23 underwent R0 resection (82%), while 5 developed progressive disease. Four patients developed anastomotic leaks (17%). Four patients had complete pathologic responses (14%) and 4 (14%) had only residual microscopic disease. Nine patients remain alive at a median follow-up of 48 months. Three-year survival for the entire cohort was 36%. Conclusion: This regimen was associated with a high rate of compliance and induction therapy had an acceptable toxicity profile. The R0 resection rate and 3-year survival data are similar to recently reported studies. While active, gemcitabine and paclitaxel induction therapy was associated with an increased rate of postoperative complications, but no increase in survival. Patterns of failure continue to demonstrate the need for regimens incorporating greater emphasis on systemic therapy for locally advanced esophageal cancer. |
| Databáze: | OpenAIRE |
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