Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level
| Autor: | Wiktoria Wojciechowska, Marek Rajzer, Krystian Gruszka, Danuta Czarnecka, T. Pizon, Tomasz Dróżdż, Kamila Migacz-Gruszka |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
arterial hypertension Blood lipids hyperuricemia Pulse Wave Analysis Clinical Cardiology Essential hypertension Carotid Intima-Media Thickness metabolic syndrome chemistry.chemical_compound Vascular Stiffness Risk Factors Internal medicine medicine Humans Hyperuricemia Pulse wave velocity business.industry matrix metalloproteinases General Medicine medicine.disease Lipids Uric Acid Endocrinology Blood pressure chemistry Hypertension Cardiology Uric acid Matrix Metalloproteinase 3 Original Article Metabolic syndrome Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Cardiology Journal |
| ISSN: | 1898-018X |
| Popis: | Background Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU). The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity. Methods One hundred and nine patients untreated with antihypertensive, hypolipemic or urate-lowering drugs with diagnosed stage 1–2 essential hypertension were included in this study. In all participants blood pressure (BP) was measured, carotid-femoral pulse wave velocity (PWV), intima–media thickness (IMT), echocardiography and blood tests including UA, lipids and serum concentrations of MMPs (1, 2, 3, 9) were observed. The participants were divided into hyper- and normuricemic groups. Results Uric acid concentration in the whole study group positively correlated with some HMOD parameters (IMT, PWV, left ventricular mass index, left atrial dimension). Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048). Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002). Patients with HU were characterized by higher activity of MMP-3 than those without (19.41 [14.45; 21.74] vs. 13.98 [9.52; 18.97] ng/mL, p = 0.016). Conclusions The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT. |
| Databáze: | OpenAIRE |
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