Anti-Diabetic and Anti-Nephritic Activities of Grifola frondosa Mycelium Polysaccharides in Diet-Streptozotocin-Induced Diabetic Rats Via Modulation on Oxidative Stress

Autor: Ling Kou, Yizhi Zhang, Mingzhao Du, Mengyuan Shang, Baohai Zhang, Xiaodong Wang, Peijing Liu, Ping Yang
Rok vydání: 2018
Předmět:
0301 basic medicine
Blood Glucose
Male
Antioxidant
medicine.medical_treatment
Pharmacology
medicine.disease_cause
Applied Microbiology and Biotechnology
Biochemistry
Blood Urea Nitrogen
chemistry.chemical_compound
Functional Food
Malondialdehyde
Diabetic Nephropathies
chemistry.chemical_classification
biology
Glutathione peroxidase
NF-kappa B
General Medicine
Catalase
Creatinine
Biotechnology
Bioengineering
Polysaccharide
Diet
High-Fat
Streptozocin
Diabetes Mellitus
Experimental
Superoxide dismutase
03 medical and health sciences
Polysaccharides
Acetylglucosaminidase
medicine
Animals
Hypoglycemic Agents
Rats
Wistar
Molecular Biology
Grifola frondosa
Reactive oxygen species
Glutathione Peroxidase
030102 biochemistry & molecular biology
Dose-Response Relationship
Drug
Interleukin-6
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Diet
Oxidative Stress
030104 developmental biology
chemistry
biology.protein
Interleukin-2
Reactive Oxygen Species
Oxidative stress
Grifola
Zdroj: Applied biochemistry and biotechnology. 187(1)
ISSN: 1559-0291
Popis: Grifola frondosa is an edible fungus with a variety of potential pharmacological activities. This study investigates the hypoglycemic, anti-diabetic nephritic, and antioxidant properties of G. frondosa polysaccharides in diet-streptozotocin-induced diabetic rats. After a 4-week treatment with 100 mg/kg of metformin and 200 mg/kg of one of four different G. frondosa polysaccharide mixtures (especially GFPS3 and GFPS4), diabetic rats had enhanced body weight and suppressed plasma glucose, indicating the hypoglycemic activities of the G. frondosa polysaccharides. G. frondosa polysaccharides regulated the level of serum creatinine, blood urea nitrogen, N-acetyl-β-d-glucosaminidase, and albuminuria; inhibited the serum levels of interleukin (IL)-2, IL-6, and TNF-α; and enhanced the serum levels of matrix metalloproteinase 9 and interferon-α, confirming their anti-diabetic nephritic activities. G. frondosa polysaccharides ameliorated the pathological alterations in the kidneys of diabetic rats. Moreover, G. frondosa polysaccharides modulated the serum levels of oxidant factors such as superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, and reactive oxygen species, revealing their antioxidant properties. Furthermore, the administration of G. frondosa polysaccharides inhibited nuclear factor kappa B activities in the serum and kidneys. All of the data revealed that the activation of nuclear factor kappa B plays a central role in G. frondosa polysaccharide-mediated anti-diabetic and anti-nephritic activities.
Databáze: OpenAIRE
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