Naloxone inhibits and morphine potentiates the adrenal steroidogenic response to ACTH
| Autor: | John P. Heybach, Joan Vernikos |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
endocrine system medicine.medical_specialty (+)-Naloxone Pharmacology chemistry.chemical_compound Adrenocorticotropic Hormone Corticosterone Internal medicine medicine Animals Drug Interactions ACTH receptor Morphine Naloxone Adrenal gland Adrenal cortex business.industry Antagonist Rats Inbred Strains Stereoisomerism Rats medicine.anatomical_structure Endocrinology chemistry Adrenal Cortex Opiate business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | European Journal of Pharmacology. 75:1-6 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(81)90337-x |
| Popis: | The administration of morphine to hypophysectomized rats potentiated the steroidogenic response of the adrenal cortex to exogenous adrenocorticotrophic hormone (ACTH) in a dose-dependent fashion. Conversely, the opiate antagonist naloxone inhibited the adrenal response to ACTH. Naloxone pretreatment also antagonized the potentiating effect of morphine on ACTH-induced steroidogenesis in a dose-dependent manner. Neither morphine nor naloxone, administered to hypophysectomized rats, had any direct effect on adrenal steroidogenesis. These adrenal actions were stereospecific since neither the (+)-stereoisomer of morphine, nor that or naloxone, had any effect on the adrenal response to ACTH. The administration of human beta-endorphin to hypophysectomized rats had no effect on the adrenal corticosterone concentration nor did it alter the response of the adrenal gland to ACTH. These results indicate that morphine can potentiate the action of ACTH on the adrenal by a direct, stereospecific, dose-dependent mechanism that is prevented by naloxone pretreatment and which may involve competition for ACTH receptors on the corticosterone-secreting cells of the adrenal cortex. |
| Databáze: | OpenAIRE |
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