Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration
| Autor: | Thiago Oliveira Farinha, Jefferson Pitelli Fonseca, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado, Renata Grespan, Gessilda de Alcantara Nogueira de Melo, Adriano Lopes Romero, Expedito Leite Silva |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Leukocyte migration Magnetic Resonance Spectroscopy Medicine (miscellaneous) Carrageenan Gas Chromatography-Mass Spectrometry Rosmarinus law.invention chemistry.chemical_compound Camphor Cell Migration Assays Leukocyte In vivo law Leukocytes Oils Volatile Animals Endothelium Rats Wistar Essential oil Nutrition and Dietetics Dose-Response Relationship Drug biology Traditional medicine Anti-Inflammatory Agents Non-Steroidal Leukocyte Adherence Inhibition Test Cell Migration Inhibition biology.organism_classification Rats Plant Leaves Chemotaxis Leukocyte chemistry Monoterpenes Scrotum Medicine Traditional Leukocyte chemotaxis |
| Zdroj: | Journal of Medicinal Food. 14:944-946 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2010.0159 |
| Popis: | Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring and in folk medicine as an antispasmodic, analgesic, antirheumatic, diuretic, and antiepileptic agent. Few studies have shown the anti-inflammatory effects of rosemary essential oil (REO). This study evaluated the effects of REO on leukocyte migration through in vivo leukocyte migration and in vitro chemotaxis assay. REO was analyzed by using gas chromatography-mass spectometry, and the main components identified were camphor (27.59%), 1,8-cineole (15.74%), α-pinene (16.58%), and β-myrcene (10.02%). In rats, administration of REO reduced the number of leukocytes that rolled, adhered, and migrated to the scrotal chamber after carrageenan injection. All doses of REO tested significantly inhibited leukocyte chemotaxis induced by casein. The effects of REO on leukocyte migration highlight an important mechanism of the anti-inflammatory action of rosemary. |
| Databáze: | OpenAIRE |
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