Cytogenetic damage in the blood lymphocytes of astronauts: Effects of repeat long-duration space missions
| Autor: | J. Rhone, Francis A. Cucinotta, A. Beitman, Kerry George |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Time Factors
Health Toxicology and Mutagenesis Population Physiology Space exploration Chromosome Painting Toxicology Biodosimetry International Space Station medicine Genetics Humans Lymphocytes education Short duration In Situ Hybridization Fluorescence Chromosome Aberrations High-LET Radiation education.field_of_study Blood Cells medicine.diagnostic_test Equivalent dose business.industry Space Flight Cytogenetic Analysis Astronauts business Cosmic Radiation Fluorescence in situ hybridization |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 756(1-2):165-169 |
| ISSN: | 1383-5718 |
| DOI: | 10.1016/j.mrgentox.2013.04.007 |
| Popis: | Human missions onboard the International Space Station (ISS) are increasing in duration and several astronauts have now participated in second ISS increments. The radiation environment in space is very different from terrestrial radiation exposure and it is still unclear if space flight effects and radiation from repeat missions are simply additive, which potentially confounds the assessment of the cumulative risk of radiation exposure. It has been shown that single space missions of a few months or more on the ISS can induce measureable increases in the yield of chromosome damage in the blood lymphocytes of astronauts, and it appears that cytogenetic biodosimetry can be used reliably to estimate equivalent dose and radiation risk. We have now obtained direct in vivo measurements of chromosome damage in blood lymphocytes of five astronauts before and after their first and second long duration space flights. Chromosome damage was assessed by fluorescence in situ hybridization technique using three different chromosome painting probes. All astronauts showed an increase in total exchanges and translocations after both the first and second flight. Biological dose measured using either individual assessment or a population assessment supports an additive risk model. |
| Databáze: | OpenAIRE |
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