Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer
| Autor: | M. Caroline Vos, Toin H. van Kuppevelt, Roy F.P.M. Kruitwagen, Harrie W. H. Feijen, Leon F.A.G. Massuger, Johan Bulten, Thijs Hendriks, Anneke A. M. van der Wurff |
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| Přispěvatelé: | Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Pathology Time Factors Kaplan-Meier Estimate Matrix metalloproteinase Metastasis 0302 clinical medicine Risk Factors Follicular phase Netherlands Aged 80 and over Ovarian Neoplasms Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] MMP-2 General Medicine Middle Aged Prognosis Immunohistochemistry Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Treatment Outcome Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] 030220 oncology & carcinogenesis MMP-14 Matrix Metalloproteinase 2 Female Adult medicine.medical_specialty Histology Stromal cell Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences Ovarian cancer Internal medicine Biomarkers Tumor Matrix Metalloproteinase 14 medicine Humans Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Proportional hazards model Activator (genetics) business.industry Research Epithelial Cells medicine.disease 030104 developmental biology Multivariate Analysis Stromal Cells business |
| Zdroj: | Diagnostic Pathology, 11:34. BioMed Central Diagnostic Pathology, 11, 34 Diagnostic Pathology, 11, 1, pp. 34 Diagnostic Pathology |
| ISSN: | 1746-1596 |
| DOI: | 10.1186/s13000-016-0485-3 |
| Popis: | Contains fulltext : 165697.pdf (Publisher’s version ) (Open Access) BACKGROUND: In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for both MMP-14 and MMP-2 in ovarian cancer. This study was designed to determine the prognostic value of MMP-14 and MMP-2 expression in ovarian cancer with data on long-term follow-up. METHODS: Tumor samples of 94 consecutive ovarian cancer patients from one regional laboratory were evaluated. Clinical and survival data were collected and related to known prognostic factors, as well as to the expression of MMP-14 and MMP-2 as determined by semi-quantitative immunohistochemistry. RESULTS: Epithelial MMP-14 expression correlated with stromal MMP-14 expression (rho = .47, p < .01) and epithelial MMP-2 expression was found to correlate with both MMP-14 epithelial and stromal expression (rho = -.28, p < .01 respectively rho = -.21, p < .05). In univariable analysis of 64 advanced-staged tumours, no MMP parameter was significant for progression-free or overall survival. In multivariable analysis for PFS, stromal MMP-14 expression and epithelial MMP-2 expression remained in the model. For overall survival, no MMP parameter showed significance. CONCLUSIONS: We confirmed the correlation between epithelial and stromal MMP-14 expression and between epithelial MMP-2 and both epithelial and stromal MMP-14 expression. In this study with long-term follow-up, the independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer is limited to a role in PFS for stromal MMP-14 expression and epithelial MMP-2 expression. |
| Databáze: | OpenAIRE |
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