Effects of hypoxia and dietary aspirin on plasma and urinary amino acids in the rat
| Autor: | Patricia R. Korty, David A. Vaughan, John L. Steele |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Endocrinology Internal medicine Casein medicine Animals Amino Acids Hypoxia chemistry.chemical_classification Aspirin Meal Altitude Metabolism Effects of high altitude on humans Hypoxia (medical) medicine.disease Diet Rats Amino acid chemistry Aminoaciduria medicine.symptom medicine.drug |
| Zdroj: | Metabolism. 18:1055-1061 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(69)90023-7 |
| Popis: | Plasma and urinary free amino acids were studied in rats receiving 0.5 percent acetylsalicylic acid (aspirin) while exposed to simulated high altitude. Rats were placed in a chamber at simulated 17,500 feet for 2 weeks. They were then fed a casein-based diet containing 0.5 percent aspirin as meals of 2 hour duration for a period of 2 weeks. Altitude and diet controls were run simultaneously. Plasma concentrations of 15 amino acids were measured at intervals of 4, 8, 15, and 22 hours after the last meal. Both aspirin and altitude modified the post prandial pattern of these amino acids. Glutamic acid levels rose sharply in the aspirin fed rats at both ground level and altitude. Dietary controls showed no such rise. Both aspirin feeding and altitude exposure depressed peak concentrations of the other amino acids independently and there were no interactions between the two treatments. Aminoaciduria did not occur in either the aspirin-fed or altitude exposed rats. Although changes in renal function cannot be entirely ruled out, it would appear that both aspirin and altitude may affect amino acid absorption and metabolism and that these effects are often additive. |
| Databáze: | OpenAIRE |
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