The research on endothelial function in women and men at risk for cardiovascular disease (REWARD) study: methodology

Autor: Jocelyn Dupuis, André Arsenault, Catherine Laurin, Denyse Gautrin, Louise Pilote, Jennifer L. Gordon, Simon L. Bacon, Kim L. Lavoie, Alain Vadeboncoeur
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Endothelium
endothelium
Brachial Artery
medicine.medical_treatment
Hyperemia
Disease
030204 cardiovascular system & hematology
Revascularization
forearm hyperaemic reactivity
03 medical and health sciences
Study Protocol
0302 clinical medicine
cardiovascular disease
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
gender
sex
Humans
Medical history
030212 general & internal medicine
Endothelial dysfunction
Angiology
Aged
Tomography
Emission-Computed
Single-Photon
Sex Characteristics
business.industry
Middle Aged
medicine.disease
3. Good health
Surgery
medicine.anatomical_structure
lcsh:RC666-701
Cardiovascular Diseases
Predictive value of tests
Exercise Test
Female
Endothelium
Vascular
Cardiology and Cardiovascular Medicine
business
Sex characteristics
Follow-Up Studies
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 11, Iss 1, p 50 (2011)
ISSN: 1471-2261
Popis: Background Endothelial function has been shown to be a highly sensitive marker for the overall cardiovascular risk of an individual. Furthermore, there is evidence of important sex differences in endothelial function that may underlie the differential presentation of cardiovascular disease (CVD) in women relative to men. As such, measuring endothelial function may have sex-specific prognostic value for the prediction of CVD events, thus improving risk stratification for the overall prediction of CVD in both men and women. The primary objective of this study is to assess the clinical utility of the forearm hyperaemic reactivity (FHR) test (a proxy measure of endothelial function) for the prediction of CVD events in men vs. women using a novel, noninvasive nuclear medicine -based approach. It is hypothesised that: 1) endothelial dysfunction will be a significant predictor of 5-year CVD events independent of baseline stress test results, clinical, demographic, and psychological variables in both men and women; and 2) endothelial dysfunction will be a better predictor of 5-year CVD events in women compared to men. Methods/Design A total of 1972 patients (812 men and 1160 women) undergoing a dipyridamole stress testing were recruited. Medical history, CVD risk factors, health behaviours, psychological status, and gender identity were assessed via structured interview or self-report questionnaires at baseline. In addition, FHR was assessed, as well as levels of sex hormones via blood draw. Patients will be followed for 5 years to assess major CVD events (cardiac mortality, non-fatal MI, revascularization procedures, and cerebrovascular events). Discussion This is the first study to determine the extent and nature of any sex differences in the ability of endothelial function to predict CVD events. We believe the results of this study will provide data that will better inform the choice of diagnostic tests in men and women and bring the quality of risk stratification in women on par with that of men.
Databáze: OpenAIRE
Externí odkaz: