Cost‐effectiveness of strategies for testing current hepatitis C virus infection
| Autor: | Chong Gee Teo, D. Robert Dufour, Rikita I. Hatia, Michael K. Chapko, John W. Ward, Jan Drobeniuc |
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| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
Venipuncture Hepatology medicine.diagnostic_test Cost effectiveness business.industry Fingerstick Cost-Benefit Analysis Point-of-Care Systems Hepatitis C virus Population virus diseases Nucleic acid test Viremia Hepatitis C Antibodies medicine.disease medicine.disease_cause Hepatitis C Nat Immunology medicine Humans RNA Viral education business |
| Zdroj: | Hepatology. 62:1396-1404 |
| ISSN: | 1527-3350 0270-9139 |
| DOI: | 10.1002/hep.27966 |
| Popis: | Six strategies for identifying hepatitis C virus (HCV) viremia, involving testing for HCV antibody (HCVAb) followed by a nucleic acid test (NAT) for HCV RNA when the antibody test is positive, are compared. Decision analysis was used to determine mean relative cost per person tested and outcomes of HCV viremia detection. Parameters included proportions of test population with HCVAb and viremia plus specificity, sensitivity, and cost of individual tests. For testing a population with an HCVAb seroprevalence of 3.25%, all strategies when adopting quantitative NAT vary little in cost (range, $29.50-$30.70) and are highly viremia specific (≥0.9997). Four of the strategies using venipuncture blood for HCVAb testing (whether laboratory conducted or employing a rapid, point-of-care assay) and for NAT (whether done by reflex or using separately drawn blood) achieve the highest viremia sensitivities (range, 0.9950-0.9954). Point-of-care HCVAb testing in fingerstick blood followed by NAT in venipuncture blood yields relatively lower viremia sensitivity (0.9301). The strategy that requires returning for NAT is even less viremia sensitive ( |
| Databáze: | OpenAIRE |
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