Effect of Semen on Vaginal Fluid Cytokines and Secretory Leukocyte Protease Inhibitor
| Autor: | Carol E. Richardson, Zandra D Lee, Norma Nunez, Jennifer F. Culhane, Kathy Agnew, Jane Hitti, Jan Aura, Rick Lawler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Article Subject Acid Phosphatase Interleukin-1beta Semen Enzyme-Linked Immunosorbent Assay Dermatology lcsh:Gynecology and obstetrics Proinflammatory cytokine lcsh:Infectious and parasitic diseases Cohort Studies Pregnancy Internal medicine medicine Humans Secretory Leukocyte Peptidase Inhibitor lcsh:RC109-216 Prospective Studies lcsh:RG1-991 biology medicine.diagnostic_test business.industry Interleukin-6 Interleukins Interleukin-8 Acid phosphatase Coitus Obstetrics and Gynecology Interleukin Sperm Protease inhibitor (biology) Infectious Diseases Endocrinology Vaginal Discharge Immunoassay Vagina biology.protein Female business SLPI medicine.drug Research Article |
| Zdroj: | Infectious Diseases in Obstetrics and Gynecology, Vol 2008 (2008) Infectious Diseases in Obstetrics and Gynecology |
| ISSN: | 1098-0997 1064-7449 |
| Popis: | The presence of semen in vaginal fluid, as identified by an acid phosphatase spot test, does not influence vaginal proinflammatory cytokine concentrations.Objective: determine whether semen, as detected by acid phosphatase, influences vaginal cytokines or secretory leukocyte protease inhibitor concentrations.Methods: 138 pregnant women had vaginal fluid collected for Gram stain, acid phosphatase detection by colorimetric assay, and interleukin 1-Beta, interleukin-6, interleukin-8, and secretory leukocyte protease inhibitor measurement by enzyme immunoassay. Results for women with and without acid phosphatase were compared by Mann-Whitney test.Results: of 138 subjects, 28 (20%) had acid phosphatase detected; of these, only 19 (68%) reported recent intercourse and 3 (11%) had sperm seen on Gram stain. There were no significant differences in proinflammatory cytokine concentrations; however, secretory leukocyte protease inhibitor concentrations were significantly higher among women with acid phosphatase.Conclusions: proinflammatory cytokine measurement does not appear to be affected by the presence of semen, but secretory leukocyte protease inhibitor is significantly higher when semen is present. Detection of semen by acid phosphatase was associated with higher vaginal SLPI concentrations, however, the presence of semen did not appear to influence vaginal proinflammatory cytokine concentrations. |
| Databáze: | OpenAIRE |
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