Quantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples
| Autor: | Skylar J. Ferrara, Jordan J. Devereaux, Thomas S. Scanlan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Bioanalysis
Thyroid Hormones Synthetic derivatives 030204 cardiovascular system & hematology Acetates 01 natural sciences Article Drug levels 03 medical and health sciences Mice 0302 clinical medicine Phenols Tandem Mass Spectrometry Lc ms ms medicine Animals Humans Sobetirome Tissue Distribution Molecular Structure 010405 organic chemistry Chemistry Thyroid Molecular Mimicry Biological tissue 0104 chemical sciences medicine.anatomical_structure Biochemistry Metabolic Networks and Pathways Hormone Chromatography Liquid |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493979011 |
| ISSN: | 1940-6029 |
| Popis: | Thyroid hormone is a principal regulator of essential processes in vertebrate physiology and homeostasis. Synthetic derivatives of thyroid hormone, known as thyromimetics, display desirable therapeutic properties. Thoroughly understanding how thyromimetics distribute throughout the body is crucial for their development and this requires appropriate bioanalytical techniques to quantify drug levels in different tissues. Here, we describe a detailed protocol for the quantification of the thyromimetic sobetirome using liquid chromatography tandem-mass spectrometry (LC-MS/MS). |
| Databáze: | OpenAIRE |
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