Total Cholesterol Level for Assessing Pancreatic Insufficiency Due to Chronic Pancreatitis
| Autor: | Natsuyo Yamamoto, Kazuhiko Koike, Tomotaka Saito, Naoki Sasahira, Minoru Tada, Y. Nakai, Tsuyoshi Hamada, Kei Saito, Hiroyuki Isayama, Koji Miyabayashi, Hirofumi Kogure, Naminatsu Takahara, Miho Matsukawa, Takashi Sasaki, Rie Uchino, Gyotane Umefune, Dai Akiyama, Dai Mohri, Suguru Mizuno, Kenji Hirano, Shuhei Kawahata |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatitis Alcoholic Nutritional Status Gastroenterology chemistry.chemical_compound Diabetes mellitus Liver Cirrhosis Alcoholic Pancreatitis Chronic Internal medicine medicine Pancreatic exocrine insufficiency Cholinesterases Humans Pancreatitis chronic Exocrine pancreatic insufficiency Pancreas Serum Albumin Aged Cholinesterase Aged 80 and over Hepatology biology Cholesterol business.industry Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Concomitant biology.protein Pancreatitis Original Article Exocrine Pancreatic Insufficiency Female business Chronic pancreatitis Follow-Up Studies |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl13366 |
| Popis: | Background/aims To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice. Methods A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups. Results The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052). Conclusions Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis. |
| Databáze: | OpenAIRE |
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