Cerebral Blood Flow Dynamics During Pain Processing in Patients With Fibromyalgia Syndrome
| Autor: | Pedro Montoya, Stefan Duschek, Andreas Winkelmann, Tanja Mannhart, Daniel Schuepbach, Karim Merzoug, Natalie S. Werner |
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| Přispěvatelé: | University of Zurich, Duschek, S |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Pain Threshold Middle Cerebral Artery medicine.medical_specialty Fibromyalgia Hot Temperature Time Factors Anterior Cerebral Artery Ultrasonography Doppler Transcranial Visual analogue scale Haemodynamic response Cerebral arteries 610 Medicine & health 3202 Applied Psychology 2738 Psychiatry and Mental Health Internal medicine Threshold of pain Humans Medicine Applied Psychology Pain Measurement business.industry Beck Depression Inventory Brain Pain Perception Cerebral Arteries Middle Aged medicine.disease Psychiatry and Mental health Cerebral blood flow McGill Pain Questionnaire 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Case-Control Studies Physical therapy Cardiology Female business Blood Flow Velocity |
| Zdroj: | Psychosomatic Medicine. 74:802-809 |
| ISSN: | 0033-3174 |
| Popis: | Objectives Increased cerebral blood flow during processing of acute pain has repeatedly been observed in fibromyalgia syndrome. The study investigated the time dynamics of the pain-related hemodynamic response in fibromyalgia using transcranial Doppler sonography. Methods In 25 women with fibromyalgia and 25 healthy participants, blood flow velocities in the anterior and middle cerebral arteries of both hemispheres were recorded, while heat stimuli of 45°C were applied to their forearms. Thermal pain threshold and subjective pain experience during stimulation were assessed, and the participants completed the McGill Pain Inventory, Beck Depression Inventory, and State-Trait Anxiety Inventory. Results The early component of the blood flow response in both anterior cerebral arteries, that is, the steep flow increase during the initial stimulation period, was more pronounced in the patients than in the controls (mean [standard deviation] = 1.28% [1.85%] versus 0.24% [1.58%], p = .04). The patients showed lower pain threshold (p = .018), stronger sensory and affective pain experience (p Conclusions The increased blood flow response in the anterior cerebral arteries reflects hyperactivity of medial structures of the neuromatrix of nociception, structures involved in the processing of affective and cognitive aspects of pain. Aberrances in cerebral blood flow related to fibromyalgia and its clinical characteristics become particularly apparent in the enhancement of the initial component of the hemodynamic response. Abbreviations FMS = fibromyalgia syndrome Abbreviations fMRI = functional magnetic resonance imaging Abbreviations fTCD = functional transcranial Doppler sonography Abbreviations ACAs = anterior cerebral arteries Abbreviations MCAs = middle cerebral arteries Abbreviations SCID = Structured Clinical Interview for Axis I Disorders Abbreviations MPQ = McGill Pain Questionnaire Abbreviations BDI = Beck Depression Inventory Abbreviations STAI = State-Trait Anxiety Inventory Abbreviations VAS = visual analog scale Abbreviations VIF = variance inflation factor Abbreviations BOLD = blood oxygen level dependent Abbreviations EEG = electroencephalography |
| Databáze: | OpenAIRE |
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