Comparative Enzyme Immunoassay of Matrix Metalloproteinases-2, -7, -9 and Their Tissue Inhibitor-2 in Tumors and Plasma of Patients with Gastric Cancer
| Autor: | E. S. Gerstein, Ivan Stilidi, A. A. Yurchenko, Li Sini, A. B. Ryabov, Mikhail Davydov, N. E. Kushlinskii, E. K. Dvorova |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty In Vitro Techniques Matrix metalloproteinase General Biochemistry Genetics and Molecular Biology Serology Immunoenzyme Techniques Stomach Neoplasms Gastric mucosa Humans Medicine Aged chemistry.chemical_classification Tissue Inhibitor of Metalloproteinase-2 medicine.diagnostic_test business.industry Cancer General Medicine Plasma levels Middle Aged medicine.disease medicine.anatomical_structure Enzyme Matrix Metalloproteinase 9 chemistry Matrix Metalloproteinase 7 Immunoassay Matrix Metalloproteinase 2 Female Lymph business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:899-902 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-010-0847-x |
| Popis: | The content of matrix metalloproteinases (MMP) -2, -7, and -9 was significantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer, respectively, the increase in the level of MMP tissue inhibitor-2 (TIMP-2) detected in 61% tumors was insignificant. Only plasma level of MMP-7 was elevated in primary patients in comparison with the control and positively correlated with the expression of this protein in the tumor. The concentration of MMP-7 was maximum in the blood of patients with tumor invasion in lymph vessels. These data suggest MMP-7 as a possible serological marker of gastric cancer. |
| Databáze: | OpenAIRE |
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