Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria
| Autor: | Carina A Thorstensson, Maria Andersson, Tore Saxne, Hanna Jönsson, Ingemar F Petersson |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Knee Joint Radiography Immunology Population Osteoarthritis General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine Arthropathy medicine Immunology and Allergy Humans education Sweden Natural course education.field_of_study business.industry Incidence Mean age Middle Aged Osteoarthritis Knee medicine.disease Prognosis Arthralgia Knee pain Early Diagnosis Chronic Disease Physical therapy Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Annals of the rheumatic diseases. 68(12) |
| ISSN: | 1468-2060 |
| Popis: | To explore the natural course of knee osteoarthritis (OA) in a middle-aged population with chronic knee pain.A population-based sample of 143 subjects (mean age 45 (range 35-54), 44% women) with knee pain (3 months) at inclusion was studied. Weight-bearing posteroanterior tibiofemoral (TF) radiographs were obtained at baseline and 12 years later, and classified according to Kellgren/Lawrence (K/L). Patellofemoral (PF) OA was determined at 5- and 12-years' follow-up using a skyline view and a cut-off point of5 mm joint space width. The ACR clinical criteria were used at baseline.Seventy-six (53%) had no TF OA (K/L 0) at baseline, but 49 had clinical OA. Overall, 65/76 (86%) developed incident TF OA over 12 years (K/Lor=1): 44/49 (90%) of the subjects with clinical OA and 21/27 (78%) without clinical OA. Progression was found in 65/67 (97%) with TF OA at baseline. Of the 84 with no PF OA at the 5-year examination, 26 (31%) developed PF OA over 7 years.A majority of the subjects with chronic knee pain developed knee OA over 12 years. It is concluded that knee pain is often the first sign of knee OA. |
| Databáze: | OpenAIRE |
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