Renal Insufficiency Induced by Parathyroid Hormone: Influence of the Calcium Antagonist Gö 6070
| Autor: | H Osswald, Bichler Kh, Walter Ludwig Strohmaier, Seeger D |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Urology chemistry.chemical_element Renal function Parathyroid hormone Calcium Internal medicine medicine Animals Renal Insufficiency Naphthyridines Rats Wistar Hyperparathyroidism business.industry Calcium channel Antagonist Calcium Channel Blockers medicine.disease Urinary calcium Rats Endocrinology chemistry Parathyroid Hormone Nephrocalcinosis business hormones hormone substitutes and hormone antagonists Glomerular Filtration Rate |
| Zdroj: | European Urology. 21:323-327 |
| ISSN: | 1873-7560 0302-2838 |
| DOI: | 10.1159/000474865 |
| Popis: | To study the pathogenesis of parathyroid-hormone-induced renal insufficiency and the influence of the new calcium channel antagonist Gö 6070 (Gödecke AG, Berlin, FRG) rats were assigned to three groups (n = 8 each): (1) control, (2) PTH, (3) PTH plus Gö 6070. PTH (30 micrograms/24 h, a nonhypercalcemic dose) was administered i.p. and Gö 6070 (1 mg/kg/24 h) p.o. for 6 days. PTH did not change plasma or urinary calcium and did not induce nephrocalcinosis. The glomerular filtration rate (GFR), however, was decreased (4.9 vs. 10.3 ml/min/kg). Concomitant administration of Gö 6070 attenuated the PTH-induced fall in GFR (6.2 ml/min/kg). |
| Databáze: | OpenAIRE |
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