Involvement of the MAPK and RhoA/ROCK pathways in PGE2-mediated CCR7-dependent monocyte migration
| Autor: | Nancy Dumais, Marc-André Allaire |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
MAPK/ERK pathway
Receptors CCR7 RHOA p38 mitogen-activated protein kinases Immunology Primary Cell Culture p38 Mitogen-Activated Protein Kinases Dinoprostone Monocytes Cell Line 03 medical and health sciences Chemokine receptor 0302 clinical medicine Cell Movement medicine Immunology and Allergy Humans Protein kinase A 030304 developmental biology Mitogen-Activated Protein Kinase 1 0303 health sciences rho-Associated Kinases Mitogen-Activated Protein Kinase 3 biology Kinase Chemistry Monocyte JNK Mitogen-Activated Protein Kinases hemic and immune systems Cell biology medicine.anatomical_structure Gene Expression Regulation biology.protein Chemokine CCL19 rhoA GTP-Binding Protein 030215 immunology CCL21 Signal Transduction |
| Zdroj: | Immunology letters. 146(1-2) |
| ISSN: | 1879-0542 |
| Popis: | Prostaglandin E(2) (PGE(2)) induces the expression of C-C chemokine receptor type 7 (CCR7) on human monocytes, thereby enabling their subsequent migration in response to CCL19 and CCL21, the natural ligands for CCR7. To date, important mediators of PGE(2)-mediated monocyte migration remain unknown. In this study, we explored the role of mitogen-activated protein kinases and the RhoA/Rho-associated protein kinase (ROCK) pathway in CCR7-dependent monocyte migration in the presence of PGE(2). Our results indicate that CCL19 binding to CCR7 promotes the activation of p38, extracellular signal-regulated kinase 1/2, and c-Jun N-terminal kinase and leads to monocyte migration. Moreover, the RhoA/ROCK pathway was essential for PGE(2)-mediated CCR7-dependent monocyte migration. |
| Databáze: | OpenAIRE |
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