Immunophenotypic Profiles of Peripheral Blood Lymphocytes in Women With Recurrent Pregnancy Losses and in Infertile Women With Multiple Failed In Vitro Fertilization Cycles
| Autor: | Jaime E. Ruiz, Alan E. Beer, Joanne Y.H. Kwak |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Infertility
Abortion Habitual medicine.medical_specialty Lymphocyte medicine.medical_treatment Immunology Autoimmunity chemical and pharmacologic phenomena Fertilization in Vitro CD5 Antigens Immunophenotyping Andrology Pregnancy Internal medicine medicine Humans Immunology and Allergy Lymphocyte Count B-Lymphocytes In vitro fertilisation biology business.industry Autoantibody Obstetrics and Gynecology hemic and immune systems medicine.disease Lymphocyte Subsets Killer Cells Natural Endocrinology medicine.anatomical_structure Reproductive Medicine Antibodies Antiphospholipid biology.protein Female CD5 Antibody business Infertility Female |
| Zdroj: | American Journal of Reproductive Immunology. 35:376-382 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.1996.tb00497.x |
| Popis: | In summary (1) Nonpregnant women with RSAs of unknown etiology have higher levels of CD56+ lymphocytes when compared to normal controls; (2) The levels of CD19+, CD56+, and CD56+/CD16+ PBL of pregnant women with RSA are significantly higher than those of multiparous pregnant normal controls; (3) Women with autoantibodies to phospholipids have significantly higher levels of elevated CD56+ and CD56+/CD16+ lymphocytes when compared to women without antiphospholipid antibodies; (4) Women with autoantibodies to nuclear components demonstrate higher numbers of CD19+/CD5+ cells compared to women without autoantibodies to nuclear components; (5) Idiopathic infertile women with multiple prior IVF failures demonstrate significantly higher levels of CD56+ pBL than normal fertile controls and the conception rate is much higher in those with CD56+ levels less than 12%; (6) Elevations of CD56+ lymphocytes to over 18% during a pregnancy is a good prognostic indicator of impending pregnancy loss. We have not seen a liveborn infant in women with levels of 18% or higher without IVIg therapy; and (7) Infertile and RSA women who fail alloimmune and autoimmune therapy have significant alterations in cellular and humoral immunity involving NK cells and CD19+/CD5+ B cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text