In Vivo Models for the Performance and Safety of BAT-90, a Novel 90-Yttrium-based Internal Radiotherapy Platform

Autor:	AMATO, ANTONINO, MCVIE, GORDON, PAGANELLI, GIOVANNI, CARRIERO, PIER LUIGI, CIANNI, ROBERTO, ETTORRE, GIUSEPPE MARIA
Rok vydání:	2022
Předmět:	Pharmacology Cancer Research General Biochemistry Genetics and Molecular Biology Research Article
Zdroj:	In Vivo
ISSN:	1791-7549 0258-851X
DOI:	10.21873/invivo.12931
Popis:	Background/Aim: BAT-90 is an innovative active implantable device designed for the irradiation of unresectable tumors (e.g., liver cancer) or surgical tumor beds, based on the combination of Yttrium-90 beta-emitting microspheres and a tissue adhesive hydrogel, currently used in cardio-vascular surgery. The rationale behind BAT-90 is to localize the Yttrium-90 activity on the administration site, while minimizing its body dispersion. Materials and Methods: The effective induction of necrosis in the target injection area was tested in a pig liver model, whereas the safety of BAT-90 was assessed and demonstrated in biocompatibility tests for acute systemic toxicity, intracutaneous reactivity, delayed hypersensitivity and subcutaneous implantation. Results: BAT-90 administration induced necrosis into the target site, while the safety experiments in the treated animals highlighted results very similar to the controls. Conclusion: BAT-90 could be considered as a safe and innovative treatment option for inoperable solid tumors of the liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181a44b04183fd3966efc2c8606e703a https://doi.org/10.21873/invivo.12931 Zobrazit plný text záznamu