Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study
| Autor: | J. van Echten, A. C. Lambrechts, M. B. Van't Veer, Jw Oosterhuis, Leendert H. J. Looijenga, Wim Timens |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Molecular Sequence Data Follicular lymphoma Chromosomal translocation Biology Translocation Genetic law.invention Testicular Neoplasms immune system diseases law Proto-Oncogene Proteins hemic and lymphatic diseases Gene expression medicine Humans Polymerase chain reaction Aged Southern blot Aged 80 and over Chromosomes Human Pair 14 Base Sequence Lymphoma Non-Hodgkin Cytogenetics Middle Aged medicine.disease Immunohistochemistry Molecular biology Lymphoma Proto-Oncogene Proteins c-bcl-2 Oncology Chromosomes Human Pair 18 Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1995.15 |
| Popis: | The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity. Images Figure 2 Figure 1 |
| Databáze: | OpenAIRE |
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