Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

Autor:	Silke Szymczak, Seraya Maouche, Stefan Blankenberg, Edith Lubos, David-Alexandre Trégouët, Philipp S. Wild, Claire Perret, François Cambien, Detlev Mennerich, Andreas Ziegler, Medea S. Eleftheriadis, Heidi Rossmann, Arne Schillert, Tanja Zeller, Maxime Rotival, Raphaële Castagné, C. Sinning, Karl J. Lackner, Werner Rust, Norbert Hubner, Laurence Tiret, Viviane Nicaud, Renate B. Schnabel, Joseph Loscalzo, Marine Germain, Carole Proust, Thomas Münzel
Rok vydání:	2010
Předmět:	Adult Male Chromosomes Human Pair 21 Cardiovascular Disorders Quantitative Trait Loci lcsh:Medicine Genome-wide association study Genetics and Genomics/Complex Traits Biology Polymorphism Single Nucleotide Monocytes Transcriptome Quantitative Trait Heritable Cell Movement Risk Factors Humans Genetic Predisposition to Disease Genetics and Genomics/Genomics Allele lcsh:Science Gene Aged Genetics Regulation of gene expression Multidisciplinary Base Sequence Genome Human Gene Expression Profiling Smoking lcsh:R Immunity Genetic Variation Genetics and Genomics Genetics and Genomics/Gene Expression Middle Aged Atherosclerosis Phenotype Human genetics Gene expression profiling Gene Expression Regulation Cardiovascular and Metabolic Diseases Female lcsh:Q DNA Probes Genome-Wide Association Study Research Article
Zdroj:	PLoS ONE, Vol 5, Iss 5, p e10693 (2010) PLoS ONE
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0010693
Popis:	BACKGROUND: Variability of gene expression in human may link gene sequence variability and phenotypes; however, non-genetic variations, alone or in combination with genetics, may also influence expression traits and have a critical role in physiological and disease processes. METHODOLOGY/PRINCIPAL FINDINGS: To get better insight into the overall variability of gene expression, we assessed the transcriptome of circulating monocytes, a key cell involved in immunity-related diseases and atherosclerosis, in 1,490 unrelated individuals and investigated its association with >675,000 SNPs and 10 common cardiovascular risk factors. Out of 12,808 expressed genes, 2,745 expression quantitative trait loci were detected (P
Databáze:	OpenAIRE
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