Controlled organocatalyzed d ,l -lactide ring-opening polymerizations: synthesis of low molecular weight oligomers
| Autor: | Danielle S. W. Benoit, S. G. Russell, Maureen R. Newman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Lactide
General Chemical Engineering Alcohol 02 engineering and technology General Chemistry Transesterification Propargyl alcohol 010402 general chemistry 021001 nanoscience & nanotechnology Ring (chemistry) 01 natural sciences Controlled release 0104 chemical sciences Catalysis chemistry.chemical_compound Polymerization chemistry Polymer chemistry 0210 nano-technology |
| Zdroj: | RSC Advances. 8:28891-28894 |
| ISSN: | 2046-2069 |
| Popis: | A systematic approach to the synthesis of organocatalyzed oligo(d,l-lactide) demonstrates that choice of initiator, catalytic ratio, and reaction time yields well-controlled oligomers. Ring-opening polymerization of d,l-lactide with the initiator α-methyl propargyl alcohol, a secondary alcohol, used in excess of 4-dimethylaminopyridine catalyst mitigates cyclicization, transesterification, and catalyst-initiated side reactions. This approach enables the design of uniform lactide oligomers for controlled release applications, such as delivery systems for drugs, prodrugs, and molecular sensors. |
| Databáze: | OpenAIRE |
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