CircCSNK1G3 up-regulates miR-181b to promote growth and metastasis via TIMP3-mediated epithelial to mesenchymal transitions in renal cell carcinoma
| Autor: | Ting Rao, Yuan Ruan, Weimin Yu, Fan Cheng, Xiaobing Yao, Wen Li, Jinzhuo Ning, Yang-Yi-Yan Song, Song-Yi-Sha Yang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Epithelial-Mesenchymal Transition Regulator Cancer metastasis Protein Serine-Threonine Kinases urologic and male genital diseases Metastasis 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Cell Movement Cell Line Tumor Medicine Humans Epithelial–mesenchymal transition Tumour suppressor gene Carcinoma Renal Cell Cell Proliferation Tissue Inhibitor of Metalloproteinase-3 business.industry Casein Kinase I Tumor Suppressor Proteins Mesenchymal stem cell Cell Biology medicine.disease Kidney Neoplasms Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Molecular Medicine Female business Kidney cancer |
| Zdroj: | Journal of cellular and molecular medicine. 26(6) |
| ISSN: | 1582-4934 |
| Popis: | Renal cell carcinoma (RCC) is the most common form of kidney cancer, with a high recurrence rate and metastasis capacity. Circular RNAs (circRNAs) have been suggested to act as the critical regulator in several diseases. This study is designed to investigate the role of circCSNK1G3 on RCC progression. We observed a highly expression of circCSNK1G3 in RCC tissues compared with normal tissues. The aberrantly circCSNK1G3 promoted the tumour growth and metastasis in RCC. In the subsequent mechanism investigation, we discovered that the tumour-promoting effects of circCSNK1G3 were, at least partly, achieved by up-regulating miR-181b. Increased miR-181b inhibits several tumour suppressor gene, including CYLD, LATS2, NDRG2 and TIMP3. Furthermore, the decreased TIMP3 leads to the enhanced epithelial to mesenchymal transition (EMT) process, thus promoting the cancer metastasis. In conclusion, we identified the oncogenic role of circCSNK1G3 in RCC progression and demonstrated the regulatory role of circCSNK1G3 induced miR-181b expression, which leads to TIMP3-mediated EMT process, thus resulting in tumour growth and metastasis in RCC. This study reveals the promise of circCSNK1G3 to be developed as a potential diagnostic and prognostic biomarker in the clinic. And the roles of circCSNK1G3 in cancer research deserve further investigation. |
| Databáze: | OpenAIRE |
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