Case-control study of migraine and risk of ischaemic stroke in young women
| Autor: | Christophe Tzourio, Annick Alpérovitch, Jacques D’Anglejan-Chatillon, Marie-Germaine Bousser, Francois Chedru, Serge Iglesias, Alain Djacoba Tehindrazanarivelo |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Migraine Disorders Population Risk Factors Internal medicine medicine Humans Risk factor education Stroke General Environmental Science education.field_of_study business.industry Smoking General Engineering Absolute risk reduction Case-control study Age Factors General Medicine Odds ratio medicine.disease Migraine with aura Cerebrovascular Disorders Migraine Case-Control Studies Physical therapy General Earth and Planetary Sciences Female medicine.symptom business Contraceptives Oral Research Article |
| Zdroj: | BMJ (Clinical research ed.). 310(6983) |
| ISSN: | 0959-8138 |
| Popis: | Objective : To determine whether migraine is a risk factor for ischaemic stroke in young women. Design : A case-control study. Setting : Five hospitals in Paris and suburbs. Subjects : 72 women aged under 45 with ischaemic stroke and 173 controls randomly selected from women hospitalised in the same centres. Main outcome measures : Ischaemic stroke confirmed by cerebral computerised tomography or magnetic resonance imaging; history of headache recorded with structured interview, and diagnosis of migraine assessed by reproducibility study. Results : Ischaemic stroke was strongly associated with migraine, both migraine without aura (odds ratio 3.0 (95% confidence interval 1.5 to 5.8)) and migraine with aura (odds ratio 6.2 (2.1 to 18.0)). The risk of ischaemic stroke was substantially increased for migrainous women who were using oral contraceptives (odds ratio 13.9) or who were heavy smokers (>/=20 cigarettes/day) (odds ratio 10.2). Conclusions : These results indicate an independent association between migraine and the risk of ischaemic stroke in young women. Although the absolute risk of ischaemic stroke in young women with migraine is low, the reduction of known risk factors for stroke, in particular smoking and use of oral contraceptives, should be considered in this group. |
| Databáze: | OpenAIRE |
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