Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Autor: Karen M. C. Curtis, Silvana Regina Perez Orrico, P.M. Sogumo, Giovana Anovazzi, Raquel M. Scarel-Caminaga, Joni Augusto Cirelli, Aline C. Viana, Rivelto Renzi, Yeon Jung Kim
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
haplotype
genotype
periodontal disease
Single-nucleotide polymorphism
Interleukin 8 receptor
alpha
Biology
gene frequency
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
Receptors
Interleukin-8A
Pharmacology
Toxicology and Pharmaceutics(all)
single nucleotide polymorphism
Genotype
genetic variability
middle aged
Genetic predisposition
medicine
cytokine
genetic polymorphism
Humans
genetics
Genetic Predisposition to Disease
Interleukin 8
human
General Pharmacology
Toxicology and Pharmaceutics
Allele frequency
Medicine(all)
chemokine receptor CXCR1
CXCR1
Biochemistry
Genetics and Molecular Biology(all)
Brief Report
Haplotype
chemokine
disease predisposition
Genetic Variation
chronic periodontitis
General Medicine
Middle Aged
medicine.disease
Chronic periodontitis
major clinical study
female
Haplotypes
Immunology
Chronic Periodontitis
Female
genetic predisposition
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Negative Results in Biomedicine
Popis: Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:26:06Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:41:56Z : No. of bitstreams: 1 2-s2.0-80155201284.pdf: 244610 bytes, checksum: 90cb2ef07bfd6b6bc7c663d5865745c4 (MD5) Made available in DSpace on 2014-05-27T11:26:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-04 Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd. UNESP - São Paulo State University School of Dentistry at Araraquara Department of Morphology, SP UNESP - São Paulo State University School of Dentistry at Araraquara Department of Oral Diagnosis and Surgery, SP UNESP - São Paulo State University School of Dentistry at Araraquara Department of Morphology, SP UNESP - São Paulo State University School of Dentistry at Araraquara Department of Oral Diagnosis and Surgery, SP
Databáze: OpenAIRE
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