Clonal karyotypic evolution in a pediatric neurofibrosarcoma
| Autor: | Inga Hägerstrand, Felix Mitelman, Carl-Magnus Kullendorff, Fredrik Mertens, Nils Mandahl, Sverre Heim, Mikael Donnér |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Monosomy Isochromosome Aneuploidy Biology Chromosome 18 Neurofibrosarcoma Genetics medicine Humans Supernumerary Retroperitoneal Neoplasms Molecular Biology Chromosome Aberrations Cytogenetics Karyotype medicine.disease Child Preschool Karyotyping Neoplasm Recurrence Local Chromosomes Human Pair 18 Chromosomes Human Pair 17 |
| Zdroj: | Cancer Genetics and Cytogenetics. 81:135-138 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(94)00214-v |
| Popis: | A retroperitoneal neurofibrosarcoma infiltrating the spine of a 2-year-old boy was investigated cytogenetically three times over a 5-month period. The first sample, from a diagnostic fine-needle aspiration biopsy, had a supernumerary i(1)(q10) as the sole clonal aberration; two cells showed monosomy 18 in addition to the isochromosome. The second sample, obtained at tumor resection 3 weeks later, had the karyotype 47,XY,+i(1)(q10), −18, +21/45,XY,−18. After 5 months, a large local recurrence was resected. The chromosome analysis showed further clonal evolution: 45,XY, +1,der(1;11)dic(1;11)(q44;q13)i(1)(q10), inv(6)(p21q12), −17. The findings indicate that formation of i(1)(q10) and loss of chromosome 18 may be early genetic events in neurofibrosarcoma development. |
| Databáze: | OpenAIRE |
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