Cell-type diversity in the bed nucleus of the stria terminalis to regulate motivated behaviors
| Autor: | Maria M. Ortiz-Juza, Rizk A. Alghorazi, Jose Rodriguez-Romaguera |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Functional role
Cell type Sequencing data Biology Anxiety Molecular heterogeneity 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Extended amygdala medicine Animals Humans 030304 developmental biology Neurons 0303 health sciences Motivation Base Sequence Brain Amygdala Brain region Stria terminalis medicine.anatomical_structure Septal Nuclei Single-Cell Analysis Neuroscience Nucleus 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 411 |
| ISSN: | 1872-7549 |
| Popis: | Over the past few decades, the bed nucleus of the stria terminalis (BNST) gained popularity as a unique brain region involved in regulating motivated behaviors related to neuropsychiatric disorders. The BNST, a component of the extended amygdala, consists of a variety of subnuclei and neuronal ensembles. Multiple studies have highlighted the BNST as playing a fundamental role in integrating information by interfacing with other brain regions to regulate distinct aspects of motivated behaviors associated with stress, anxiety, depression, and decision-making. However, due to the high molecular heterogeneity found within BNST neurons, the precise mechanisms by which this region regulates distinct motivational states remains largely unclear. Single-cell RNA sequencing data have revealed that the BNST consists of multiple genetically identifiable cell-type clusters. Contemporary tools can therefore be leveraged to target and study such cell-types and elucidate their precise functional role. In this review, we discuss the different subsets of neurons found in the BNST, their anatomical distribution, and what is currently known about BNST cell-types in regulating motivated behaviors. |
| Databáze: | OpenAIRE |
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