Effect of Highly Active Antiretroviral Therapy on Tacrolimus Pharmacokinetics in Hepatitis C Virus and HIV Co-Infected Liver Transplant Recipients in the ANRS HC-08 Study
| Autor: | Elina Teicher, Aurélie Barrail, Jean-Charles Duclos-Vallée, Alain Boissonnas, Isabelle Vincent, Anne-Marie Taburet, Chadi Abbara, Laurence Bonhomme-Faivre, Daniel Vittecoq, Didier Samuel |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Cyclopropanes Graft Rejection Male medicine.medical_specialty Efavirenz HIV Infections chemical and pharmacologic phenomena Pyrimidinones Biology Gastroenterology Lopinavir Tacrolimus chemistry.chemical_compound Antiretroviral Therapy Highly Active Internal medicine medicine Humans Pharmacology (medical) Aged Pharmacology Nelfinavir Ritonavir Dose-Response Relationship Drug Reverse-transcriptase inhibitor HIV virus diseases Hepatitis C Middle Aged Viral Load medicine.disease Virology Benzoxazines CD4 Lymphocyte Count Liver Transplantation surgical procedures operative chemistry Alkynes Area Under Curve Female Liver function Half-Life medicine.drug |
| Zdroj: | Clinical Pharmacokinetics. 46:941-952 |
| ISSN: | 0312-5963 |
| Popis: | To characterise the interactions between tacrolimus and antiretroviral drug combinations in hepatitis C virus-HIV co-infected patients who had received a liver transplant. An observational, open-label, multiple-dose, two-period, one-sequence design clinical trial in which patients received tacrolimus as an immunosuppressive therapy during the postoperative period and then had an antiretroviral drug regimen added. Tacrolimus pharmacokinetics were evaluated at steady state during these two periods. Fourteen patients participated in the study and seven participated in the intensified pharmacokinetic protocol. Patients were included if they had undergone liver transplantation for end-stage chronic hepatitis C, absence of opportunistic infection, a CD4 cell count of >150 cells/μL and an undetectable HIV plasma viral load ( |
| Databáze: | OpenAIRE |
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