GK-2 Reduces Death of Cultured Granule Neurons in Cerebellum Induced by the Toxic Effects of Zinc Ions
| Autor: | Nickolay K. Isaev, I. N. Sharonova, O. P. Aleksandrova, Svetlana Novikova, E. E. Genrikhs, Elena V. Stelmashook, P D Rogozin, Vladimir G. Skrebitsky, T. A. Gudasheva |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cerebellum Long-Term Potentiation Primary Cell Culture Neurotransmission Hippocampal formation Neuroprotection Synaptic Transmission General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Chlorides medicine Animals Cytotoxicity CA1 Region Hippocampal Neurons Chemistry Glutamate receptor Long-term potentiation General Medicine Dipeptides Microtomy CA3 Region Hippocampal Cell biology Rats 030104 developmental biology medicine.anatomical_structure Nerve growth factor Neuroprotective Agents nervous system Zinc Compounds Synapses 030217 neurology & neurosurgery Copper |
| Zdroj: | Bulletin of experimental biology and medicine. 168(4) |
| ISSN: | 1573-8221 |
| Popis: | Peptide mimetic of nerve growth factor GK-2 in a dose of 1-2 mg/liter improves survival of cultured rat cerebellar granule neurons exposed to the cytotoxic effect of zinc ions, but has no protective effect against copper ion cytotoxicity. Experiments on cultured rat hippocampal slices demonstrated that GK-2 did not affect reactivity of pyramidal neurons and long-term potentiation in the hippocampal field CA1 and the probability of glutamate release from presynaptic terminals in the synapses of the CA3-CA1 fields. The results suggest that GK-2 does not affect the functional properties of synaptic transmission under normal conditions, but protects neurons from the toxic effects of zinc, which creates prerequisites for GK-12 use in the treatment of neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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