Preparation and in vivo circulation of human platelets preserved with combined dimethylsulfoxide and dextrose
| Autor: | Albert J. Roy, Isaac Djerassi, John A. Cavins, Sidney Farber |
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| Rok vydání: | 1966 |
| Předmět: |
Blood Platelets
Pathology medicine.medical_specialty Acute leukemia Leukemia business.industry Immunology Anemia Aplastic Hematology medicine.disease Thrombocytopenia Andrology Glucose In vivo Blood Preservation medicine Immunology and Allergy Humans Platelet Blood Transfusion Dimethyl Sulfoxide Aplastic anemia business |
| Zdroj: | Transfusion. 6(6) |
| ISSN: | 0041-1132 |
| Popis: | Human platelets preserved by freezing to –196 C in plasma containing 5% dextrose and 5% dimethylsulfoxide were administered to 35 thrombocytopenic patients with acute leukemia or aplastic anemia on 70 occasions. The platelet counts of the recipients increased, indicating in vivo circulation of the transfused preserved platelets. The average in vivo yield of these transfusions was only 30 per cent of the yield observed with fresh material although on occasion the in vivo recovery was as high as with fresh platelets. Preservation of human platelets without loss of viability may therefore be possible. The clinical use of platelets preserved by the above method may be considered in emergencies when speedy procurement of fresh material is not practical. |
| Databáze: | OpenAIRE |
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