Stable integration of adenovirus DNA is not required for the induction of mutations in the hypoxanthine phosphoribosyltransferase gene in Chinese hamster cells
| Autor: | Leda H. Raptis, Majambu Mbikay, Jean-Paul Thirion, Joseph Weber, Aristide Comlan de Souza |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Hypoxanthine Phosphoribosyltransferase
Genes Viral viruses Reversion Chinese hamster Cell Line chemistry.chemical_compound Cricetulus Cricetinae Animals Gene Hypoxanthine biology Adenoviruses Human Structural gene General Medicine Cell Transformation Viral biology.organism_classification Molecular biology enzymes and coenzymes (carbohydrates) Phenotype Genes chemistry Hypoxanthine-guanine phosphoribosyltransferase DNA Viral Mutation DNA |
| Zdroj: | Mutation Research Letters. 105:371-375 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(82)90109-9 |
| Popis: | Adenovirus type 2 induces EMS-like mutations at the hpt13 locus coding for hypoxanthine phosphoribosyl transferase (HPRT) in Chinese hamster cells (J. Virol., 38, 184--190, 1981). In this report we show that: (a) the hpt- 13 mutation is in the structural gene of HPRT, (b) adenovirus induces intracistronic reversion mutations which suppress the hpt- 13 phenotype, and (c) the stable integration of adenovirus DNA is not required for the induction of these mutations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|