Impact of delay in diagnosis and treatment-initiation on disease stage and survival in oral cavity cancer: a systematic review
| Autor: | Christian Grønhøj, Christian von Buchwald, Benedicte Bitsch Lauritzen, Jakob Schmidt Jensen, Irene Wessel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Male medicine.medical_specialty Delayed Diagnosis Disease Oral cavity 030218 nuclear medicine & medical imaging Patient delay Time-to-Treatment 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Neoplasm Staging business.industry Cancer Hematology General Medicine medicine.disease 030220 oncology & carcinogenesis Female Mouth Neoplasms business |
| DOI: | 10.6084/m9.figshare.14690727.v1 |
| Popis: | This study aimed to systematically review the literature on the impact of delay in diagnosis and treatment of oral cavity cancer. PubMed and Embase were systematically searched for articles reporting impact of delay in diagnosis and treatment on cancer-stage and survival of oral cavity cancer. Studies comprising at least ten patients, and published since the year 2000, were included. Sixteen studies (n = 45,001, range: 62–18,677 per study, 83% men), from Australia, Asia, Europe, North America and South America, met the inclusion criteria. Eleven studies (n = 1,460) examined delay in diagnosis, while five studies (n = 43,541) reported delay in treatment. Eight of the eleven studies, examining delay in diagnosis (n = 1,220), analyzed the correlation between delay in diagnosis and tumor stage at diagnosis. Three studies found a significant correlation between patient delay and advanced stage at diagnosis (p p p p A significant correlation between patient delay and advanced stage cancer was reported in Asian studies only, while professional delay and total diagnostic delay were generally found to be non-correlated with advanced stage cancer at diagnosis. TTI was in some studies reported to be correlated with poorer outcome, while other studies did not report a correlation. One study presented that there was no clear advantage in overall survival (OS) for patients treated within 30 days, compared to patients treated between 30 and 44 days. |
| Databáze: | OpenAIRE |
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