A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus

Autor: Fiona M. O’Prey, Dennis Johnston, Michelle T McHenry, William J. Leahey, Gary E. McVeigh, A. L. Bell, Adrian Devine, Stephen A. Wright, Michael B. Finch, Emeir M Duffy
Rok vydání: 2007
Předmět:
Adult
Male
medicine.medical_specialty
Systemic disease
Brachial Artery
Docosahexaenoic Acids
Vasodilator Agents
Immunology
medicine.disease_cause
Dinoprost
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Statistics
Nonparametric
Nitroglycerin
Rheumatology
Double-Blind Method
immune system diseases
Internal medicine
Fatty Acids
Omega-3
Immunology and Allergy
Medicine
Humans
Lupus Erythematosus
Systemic
skin and connective tissue diseases
chemistry.chemical_classification
Systemic lupus erythematosus
business.industry
Therapeutic effect
Cell Membrane
Middle Aged
medicine.disease
Fish oil
Connective tissue disease
Vasodilation
Treatment Outcome
chemistry
Eicosapentaenoic Acid
Regional Blood Flow
Ultrasonography
Doppler
Pulsed
Dietary Supplements
Fatty Acids
Unsaturated
Female
Endothelium
Vascular
business
Oxidative stress
Biomarkers
Polyunsaturated fatty acid
Zdroj: Annals of the rheumatic diseases. 67(6)
ISSN: 1468-2060
Popis: To determine the clinical effect of dietary supplementation with low-dose omega-3-polyunsaturated fatty acids on disease activity and endothelial function in patients with systemic lupus erythematosus.A 24-week randomised double-blind placebo-controlled parallel trial of the effect of 3 g of omega-3-polyunsaturated fatty acids on 60 patients with systemic lupus erythematosus was performed. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and British Isles Lupus Assessment Group index of disease activity for systemic lupus erythematosus (BILAG), endothelial function using flow-mediated dilation (FMD) of the brachial artery, oxidative stress using platelet 8-isoprostanes and analysis of platelet membrane fatty acids were taken at baseline, 12 and 24 weeks.In the fish oil group there was a significant improvement at 24 weeks in SLAM-R (from 9.4 (SD 3.0) to 6.3 (2.5), p0.001); in BILAG (from 13.6 (6.0) to 6.7 (3.8), p0.001); in FMD (from 3.0% (-0.5 to 8.2) to 8.9% (1.3 to 16.9), p0.001) and in platelet 8-isoprostanes (from 177 pg/mg protein (23-387) to 90 pg/mg protein (32-182), p = 0.007).Low-dose dietary supplementation with omega-3 fish oils in systemic lupus erythematosus not only has a therapeutic effect on disease activity but also improves endothelial function and reduces oxidative stress and may therefore confer cardiovascular benefits.
Databáze: OpenAIRE
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